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This is the data behind the muscle-and-nutrient concern, drawn from the largest claims analysis to date , Butsch and colleagues' retrospective study of 461,382 US adults newly prescribed GLP-1RAs (Butsch et al., Obesity Pillars, 2025

[DOI] [PubMed] [Google Scholar] 150.Zhang W, Li J, Liu LW, Wang KR, Song JJ, Yan JX, et al

Keep in mind that caffeine can come from other sources, such as chocolate, energy or protein bars, and some OTC medications

In response to criticisms about its expensive GLP-1 drugs, Novo Nordisk says the prices reflect substantial R&D investments, and that theyve already declined 40% with rebates