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If the uptake did not increase after addition of intrinsic factor the B12 malabsorption was likely to be caused by an intestinal condition

BDNF-Adjacent Pathways: While GHK-Cu does not directly upregulate BDNF (Brain-Derived Neurotrophic Factor), its anti-inflammatory effects in the CNS specifically its reduction of microglial activation may create conditions conducive to BDNF signaling

The cystine/glutamate antiporter system xc in health and disease: From molecular mechanisms to novel therapeutic opportunities

Avoid temptation increasing dose or frequency thinking "more is better." Stable effective protocol through completion then reassess need for continued treatment versus tapering