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B12 reduces circulating levels of homocysteine, a compound linked to increased risk of heart attack and stroke

The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison

Immediate : Some notice better energy or alertness within 2448 hours

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