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GLP-1 has a variety of effects, originating from the presence of its receptors in specific nuclei of the lung, pancreas, gastrointestinal tract, kidney, heart, bone, central nervous system, etc

Long-term inflammation is linked to: Type 2 diabetes Heart disease Fatty liver (NAFLD/NASH) Obesity Autoimmune and gut disorders Experts believe metabolic inflammation is a root cause of insulin resistance and poor cardiovascular outcomes

doi: 10.1111/dom.13343

For context on how retatrutide compares to other options, the retatrutide vs semaglutide comparison and retatrutide vs tirzepatide comparison provide detailed analysis