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3.3 Risk assessment of bias in included studies Assessment of the 10 included trials using RoB 2.0 (Figure 2) revealed an overall risk of bias categorized as some concerns. Key methodological issues included inadequate randomization and allocation concealment, unclear blinding of outcome assessors, and potential selective reporting due to discrepancies between the registration protocol and the final published results

The Pearson correlation coefficient was computed to assess the linear relationship between variables, with a 95% confidence interval, using Graph-Pad Software

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Paired-reference work with GHRH analogs (sermorelin, CJC-1295, Tesamorelin) for studies that require simultaneous activation of the GHRH-receptor and ghrelin-receptor pathways in the same experimental system