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It has been shown that in patients with type 2 diabetes mellitus (T2DM) the response to the incretin effect is altered as a result of a severe defect in the sensitivity for GIP in the cells [4] and a reduction in food-induced GLP-1 secretion [5, 6]
However, there are significant safety considerations and clinical steps to navigate first
For more frequent symptoms, histamine-2 receptor antagonists (H2RAs) such as famotidine may be used, though patients should be counseled that these medications may take 30-60 minutes to provide relief
While they've shown promise in helping with weight management and potentially improving mood, they aren't a one-size-fits-all solution
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