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Semaglutide downregulates the transcription factor PPARG, thereby reducing its inhibition of the downstream molecule ACSL1, leading to increased ACSL1 expression and promoting M1 polarization, ultimately enhancing the anti-tumor effects [95]

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While a definitive causal relationship has not been established, the occurrence of acute pancreatitis necessitates immediate drug withdrawal, as recommended by the American Diabetes Association and the American College of Cardiology ( Treatment cessation should also be considered in patients who develop gallbladder complications, such as acute cholecystitis

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