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It has been demonstrated that tPA and fibrin trigger elevation of proinflammatory and procoagulant proteins and reduce tight junction proteins in the endothelial cells

Another food derivative, epigallocatechin 3 gallate, a component of polyphenols derived from green tea, was shown to be a potent inhibitor of IL-1-induced MUC5AC gene expression and MUC5AC secretion[97] and has antioxidant activity [98]

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