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The FDA-approved dosing schedule for tirzepatide begins at 2.5 mg weekly, increasing by 2.5 mg increments every 4 weeks as tolerated, up to a maximum of 15 mg weekly for Mounjaro (diabetes) or 15 mg weekly for Zepbound (weight management)

By integrating waveform quality with thoughtful interpretation of MAP, PP, DAP, SAP, and derived indices, clinicians can individualize hemodynamic management, avoid unnecessary escalation, and better align interventions with underlying pathophysiology

We appreciate commenters' suggestions to conduct additional testing before implementation and to provide additional Safety of Care measure group information

Even with a healthy diet and regular exercise, many people struggle with small pockets of stubborn fat that wont go away