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J., Reeves, N

Increased mitochondrial NAD+ may promote the activity of SIRT4, an inducer of adipogenesis, while decreased nuclear NAD+ may decrease the activity of SIRT1, a negative regulator of adipogenesis ( via multiple independent mechanisms

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Importantly, neuroinflammatory processes are closely intertwined with oxidative stress and mitochondrial dysfunction, as inflammatory mediators increase reactive oxygen species production and compromise mitochondrial bioenergetics, further amplifying neuronal vulnerability (33)