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Introduction Although adiposity is linked to numerous diseases, adipocytes are critical for maintaining healthy systemic metabolism

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Additionally, insulin deficiency decreases the expression of a number of genes necessary for target tissues to respond normally to insulin such as glucokinase in liver and the GLUT4 class of glucose transporters in adipose tissue and skeletal muscle

Cytokine expression is controlled at the transcriptional level by pro-inflammatory transcription factors, such as nuclear factor kappa B (NF-B) and activator protein-1 (AP-1) (97)