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Improvements in body composition, deep sleep quality, and IGF-1 levels are documented in small trials, though long-term cancer risk monitoring of IGF-1 is necessary

Other documented findings include a tendency toward IGF-1 receptor desensitization with prolonged, continuous exposure, transient fluid retention in early study phases, and at supraphysiological exposure levels examined in some research acromegaly-like tissue changes

A dose of experimental hormesis: When mild stress protects and improves animal performance

It also activates AMPK signaling pathways in neural tissues, enhancing autophagy and improving neuronal energy metabolism