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Microendoscopic calcium imaging in vivo showed that the spontaneous calcium transient frequency of DMV Ach neurons was significantly decreased after morphine treatment (Fig

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Furthermore, in another study [47, 60], one semaglutide analogue demonstrated a binding affinity to GLP-1R that is more than two orders of magnitude (113.3 times) higher than native semaglutide, achieving a K d of 3.0 10 8 M compared to the K d of 3.4 10 6 M for native semaglutide