Clinical trials evaluating semaglutide have primarily focused on glycaemic control, cardiovascular outcomes, and weight reduction, with adverse event monitoring centred on gastrointestinal tolerability, hypoglycaemia risk, and complications such as pancreatitis or diabetic retinopathy progression
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According to Grigson, Because our preliminary data suggested that patients did better in the study if they were on both the GLP-1 drug and medication for opioid use disorder, in this study, half of the participants will be on methadone and half will be on buprenorphine for opioid use disorder treatment. Because semaglutide is stronger, is dosed weekly instead of daily, and has fewer gastrointestinal side effects than liraglutide, it may be even more effective in reducing craving while increasing real-world treatment adherence
Patients may gradually return to previous eating patterns, including consumption of high-calorie foods, frequent snacking, or inadequate physical activity
