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Open research questions Optimal dosing schedule (pulsatile vs continuous), combination effects with GHRH analogues (CJC-1295), long-term IGF-1 elevation safety profile

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Nevertheless, transcriptional modifications may also lead to delays in recovery, as ongoing perturbations on a transcriptional level were observed for up to 6 months after infection, with PASC patients showing a distinct profile, such as upregulation of the alarmins S100A8 and HMGB1, mediators and markers of innate immune activation (124)