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3 Pathogenesis and treatment of migraine 3.1 Etiology and inducements of migraine Migraine is a complex disorder with diverse etiologies, and various types of migraines may arise from different triggers

36 Unlike the BBB that acts as a shield against entry of polar and large molecules, the CVOs are sur- rounded by an extensive network of permeable blood vessels, facilitating the exchange of molecules and neurons with the bloodstream

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Notoriously, both GIPR agonists and antagonists lead to weight loss mainly when co-administrated with GLP-1 agonists or analogues (Killion et al