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Taking the medication with food, staying hydrated, eating smaller portions, and using anti-nausea medication during peak weeks (6-8) dramatically improves tolerability

Methylene blue has been used in medicine for cyanide poisoning and treating malaria, though not as much today

A large retrospective cohort study revealed that T2DM patients treated with GLP-1RAs exhibited a significantly reduced risk of developing dementia compared with those receiving other glucose-lowering therapies

The development of an optimal therapy is, however, complicated by certain side effects, including the possibility of post-treatment hypothyroidism and recurrence of hyperthyroidism following an initial successful treatment