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Acknowledgements This study was supported by the National Natural Science Foundation of China (#82573486, 82173088, 82203088), the Natural Science Foundation of Guangdong (#2022A1515012383, 2023A1515010377), Fundamental Research Funds for the Central Universities, Sun Yat-sen University (23ptpy168), and Baiqiuen Fund to K.L

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Since clinical trials failed to show the effectiveness of Ipamorelin, its official production has been discontinued