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Interstitial cystitis in the UK: results of a questionnaire survey of members of the Interstitial Cystitis Support Group

The biggest reduction in enzyme production are seen in people homozygous for C677T, with enzyme production reduced by up to 70%

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As to why the epidemiological connection, we reason that one possible clue is the established cancer statistics: A single mutation is insufficient to elicit cancer, although exactly how many mutations are required for cancer to emerge has been a debated question (Tomlinson et al., 2002