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To date, there has been no treatment discovered that combines glutamine metabolism and chemotherapy, and a combination of the two may result in unintended consequences

In addition, ROS induce matrix degeneration through the upregulation of matrix-degrading enzyme expression while this effect is abolished by antioxidant treatment 123,125

Summary of evidence on comprehensive healthcare for chemotherapy-induced peripheral neuropathy in cancer patients

Indeed, the development of integrity characteristics in the cerebrovascular tree requires organized cells interactions from glial cells (i.e., astrocytes, microglia), pericytes, and neurons