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Some peptides are FDA-approved prescription medications, some are legally compounded by licensed pharmacies with a prescription, and many of the ones sold online as research chemicals are not legal for human use at all

something most other glutathione supplements dont provide as it requires an extra step (and expense) in the manufacturing process

The form of the peptide determines whether the exposure causes reversible or irreversible damage

A nested case control study, where people with MASLD were identified using Medicare claims data and matched to controls without liver disease by birth year, ethnicity, and Medicare enrollment duration, reported that both estrogen-only HRT (OR 1.18, 95% CI 1.00-1.38) and combined estrogen and progesterone HRT (OR 1.25, 95% CI 1.07-1.46) were associated with a higher risk of MASLD compared to postmenopausal women with no history of HRT use (128)