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## Cost Comparison (March 2026 Estimates) | Medication | Brand Monthly | Compounded Monthly | |------------|--------------|-------------------| | Semaglutide | $900-1,300 | $200-400 | | Tirzepatide | $1,000-1,200 | $250-500 | | Retatrutide | N/A | $300-600 | | Liraglutide | $1,300-1,500 | $300-500 | Insurance coverage varies significantly by plan and indication

Restoring Mecp2 in microglia postnatally extends lifespan (Cronk et al., 2015)

MK-677 is orally bioavailable and shelf-stable, making it logistically simpler for non-laboratory settings

Cysteine oxidation produces disulfide bonds, sulfenic acid, sulfinic acid, and ultimately sulfonic acid