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It corresponds to the last 15 amino acids of human growth hormone (positions 177-191) with an extra tyrosine added at one end to stabilize the molecule

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From the genetics angle, there are some pediatric, congenital causes of 5-oxoprolinuria which not surprisingly involved defects in enzymes of the gamma-glutamyl cycle (in particular, mutations in glutathione synthetase and 5-oxoprolinase have been identified in these patients).