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Nutrition drives durability, with a clear protein goal and fiber intake supporting fullness and lean mass

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p=0.0022)

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Which means it is possible, in principle, to design molecules that produce the parts of the GLP-1 effect that you want (appetite suppression, glycemic control, cardiovascular benefit) while minimizing the parts that you do not (gastrointestinal misery, certain forms of receptor downregulation, possibly some of the off-target effects we are still characterizing)

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Though it isn't life-threatening, its an extremely serious and painful condition that currently has no cure

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