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Studies have shown that mitochondria-associated ER membranes (MAMs), the ER part directly connected to the mitochondria, participate in the pathogenesis of AKI by regulating calcium signaling, lipid metabolism and energy homeostasis (Ye et al., 2022

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However, no significant changes in gut microbiota composition were detected ( 3.4.4.2 Prebiotics In a male rat model of PTSD-like symptoms induced via amygdala hyperactivation (a key pathophysiological mechanism of PTSD)3 weeks of treatment with the prebiotic GOS restored microbial homeostasis by enriching beneficial Bifidobacterium animalis and Limosilactobacillus reuteri , while eliminating harmful Enterococcus casseliflavus (Ruciski et al., 2025)