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Weight regain after discontinuation of GLP-1 class medications is well-documented the STEP 1 extension trial showed that most weight lost on semaglutide was regained within a year of stopping treatment

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Long-term BPC-157 improves the ability to create new neurons, increases BDNF, and enhances nervous system plasticity and cognition. No scientific evidence found supporting claims about BPC-157's long-term effects on neurogenesis, BDNF, and cognitive enhancement