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Pregnant, breastfeeding, or kidney/liver patients should avoid this treatment

[DOI] [PubMed] [Google Scholar] 58.Armoza A., Haim Y., Bashiri A., Wolak T., Paran E

Additionally, there is potential for functional interaction between incretin receptors and other GPCRs, including the SCFA-activated FFARs, to occur in the islets of Langerhans (as previously discussed), but also in the gut and the hypothalamus, all of which could influence incretin therapy responses

Furthermore, as outlined previously IGF signalling is integrated with nutritional status and metabolism and now more than ever a focus on lifestyle interventions such as diet and exercise is necessary