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Brief, isolated palpitations that are clearly linked to periods of poor hydration or high GI symptom burden are more likely to be manageable with the strategies outlined above

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The down-regulation of influx transporters of 6-mercaptopurine including SLC28A2 (CNT2), SLC28A3 (CNT3), SLC29A1 (ENT1) and SLC29A2 (ENT2) has been shown to render lymphocyte-derived cell-lines resistant to thiopurines, owing to decreased uptake of thiopurine metabolites into the cells (Peng et al., 2008

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