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However, for individuals actively managing complex, reactive chronic illnesses like Long COVID, ME/CFS, or severe dysautonomia, such high starting doses are rarely recommended due to the high potential for gastrointestinal upset or rapid, uncomfortable detoxification reactions (often referred to as a Herxheimer reaction)

A 2023 study found that the antioxidant effects of silymarin can stimulate anti-tumor activities as well as protect healthy cells from damage induced by chemotherapy

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If weight loss is your ultimate goal, daily caloric intake becomes increasingly important