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Treatment with picomolar to nanomolar concentrations of Dihexa produces dose-dependent increases in spine density, with maximal effects observed at 10-12 M concentrations

As overall hydrophobicity of TCTP-PTD variants (Kim et al., 2011b) and 1-MIIFR-5 and 9-SHKK-12 residues of TCTP-PTD 13 are favorable for intranasal transduction and solubility, the residues 6-ALI-8 were considered for amino acid residue substitution ( Interestingly, the altered stereochemistry of TCTP-PTD variants was not necessarily favored because both D-TCTP-PTD 13 and D-TCTP-PTD 13M2 did not exhibit enhanced uptake compared to their L-counterparts (Khafagy et al., 2009a)

Slide backs were tapped on padding and dried with paper towels and then placed section side up on a benchtop slide warmer, setting 4 for 1 h or until sections were opaque and all droplets had dissolved

Use: Intended solely for laboratory research