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These results have been successfully replicated in studies using other animal models
Given that mitochondrial bioenergetic alterations appear early in the disease course, they are considered potential primary events underlying synaptic failure, neuroinflammation, oxidative stress, and neuronal loss (Joshi et al., 2018)
Marias story is not just a local problem
The authors write that they suspect the two medications had synergistic effects in the patient, leading to adequate control of his blood sugars yet a state of starvation, ketone production, and resultant systemic acidification
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