In the lungs, after entering in type II alveolar cells, SARS-CoV-2 infected cells become defective for surfactant production (Ghati et al., 2021) and release cytokines, like IL-8 among others, which in turn activate alveolar macrophages to release IL-1, IL-6, and TNF-, that induce natural killer and dendritic cell differentiation and macrophage M1 polarization, enhancing the proinflammatory response with increased vasodilation causing neutrophil and activated T cell influx from the capillaries into the alveolus, all leading to the cytokine storm (Carcaterra and Caruso, 2021
When glutathione levels are depleted - as they consistently are in Hashimoto's thyroiditis, Graves' disease, and hypothyroidism - the consequences cascade: oxidative thyroid damage, protein modification, autoantigen formation, immune activation, and progressive thyroid destruction
Therapeutic Research Protocol Dose: 300 600 mcg (1 2 capsules) Duration: 6 10 weeks Frequency: Once daily, preferably before physical-activity windows Cycle Interval: 3 4 weeks off before repeating Goal / Description: Used in research targeting endurance, fat oxidation, and ERR pathway activation
Discussion Our results showed that green tea extract at doses of 50, 100 and 200 mg/kg significantly reduced the elevated activities of serum aminotransferases (ALT and AST), alkaline phosphatase and increased the production of proteins including albumin compared to the thioacetamide-treated group