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Treatment with 2-DG has been shown to inhibit IL-6 in RA-FLS 29

These might include: Blood tests to assess for coeliac disease, inflammatory markers, or thyroid function Breath tests for lactose intolerance or small intestinal bacterial overgrowth Abdominal imaging (ultrasound or CT) if structural abnormalities are suspected Faecal calprotectin if inflammatory bowel disease is a concern Referral to gastroenterology for specialist assessment if symptoms persist despite initial management The MHRA's Yellow Card scheme allows patients and healthcare professionals to report suspected side effects of medications, including GLP-1 agonists

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