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The safety profile is well-characterized with known adverse event patterns, including gastrointestinal tolerability concerns and rare reports of medullary thyroid carcinoma and pancreatitis

Firstly, not everyone is a good candidate or can safely take the medication

Approximately 1,500 patients with T2D and Early Treatment Diabetic Retinopathy Study (ETDRS) level of 1075 in both eyes and no ocular or intraocular treatment for diabetic retinopathy or diabetic macular edema in the 6 months prior to screening will receive once-weekly subcutaneous semaglutide 1.0 mg or placebo for up to 5 years, with the primary endpoint of progression of 3 steps or more in ETDRS level

It's nuanced, and it deserves a thorough, honest discussion