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Strategies to reduce the issue: Take with food (for oral formulations) Follow administration with a beverage Consider alternative delivery formats (injection, topical) if taste is bothersome Time doses to minimize coincidence with meals where possible Other Safety Considerations Pregnancy and lactation
The papers published before August 2012 are reviewed herein
While there are studies on the role of MTX-induced oxidative stress in liver and kidney damage (Reference Uraz, Tahan and Aygun5,Reference Jahovic, Cevik and Sehirli38Reference Moghadam, Tutunchi and Namvaran-Abbas-Abad40) , there is no study related to the effect of whey proteins on MTX-induced liver and kidney damage
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