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Mechanisms of disease: pathogenesis of Crohns disease and ulcerative colitis
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For context, most GLP-1 medications require consistent use for weeks or months to start working at full therapeutic capacity
In addition, GLP-1RAs increase heart rate in humans, most likely via the GLP-1R located in the sinoatrial node of the heart (37) and perhaps also via activation of the sympathetic nervous system and inhibition of the parasympathetic nervous system as shown in animals studies (38, 39)
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