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They may appear as brown to black patches or spots and are usually asymptomatic

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[11] For instance, the cytosol typically exhibits a E GSH between -315 and -325 mV, [12,13] with GSH concentrations ranging between 1 and 20 mM, [3] whereas mitochondria possess an independent redox pool characterized by a narrow GSH concentration range (5-10 mM), and a significantly lower redox potential of approximately -360 mV