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SARS-CoV-2 mediated endothelial dysfunction: the potential role of chronic oxidative stress

[DOI] [PMC free article] [PubMed] [Google Scholar] Nandi A, Yan LJ, Jana CK, Das N

Methylfolate is required in the activation of tetrahydrobiopterin (i.e., BH4), which is a necessary cofactor for both tryptophan hydroxylase and tyrosine hydroxylase, enzymes required in the synthesis of serotonin and norepinephrine/dopamine, respectively (Figure 1)