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In summary, GLP-1 RAs represent a promising therapeutic option for obese patients with HFpEF, but their large-scale adoption will require further evidence of efficacy, safety, and long-term benefits through rigorous and well-designed clinical trials

At present, the most defensible conclusion is implementation-oriented rather than economic: access, reimbursement, equity, and opportunity cost are likely to shape uptake more strongly than efficacy alone (204, 205)

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