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We also tested a non-CRC model, the osteosarcoma U2OS cell line, which is wild-type for APC, KRAS and p53, and confirmed a similar 5FU-driven change in mitochondrial mass and morphology (Extended Data Fig

Zepbound vs semaglutide Zepbound (tirzepatide) and semaglutide are highly effective, once-weekly injectable medications for weight loss that work by mimicking satiety hormones

MMS was a Lundbeck postdoctoral fellow

While a 5% weight reduction is commonly considered clinically meaningful at the individual level [33], smaller differences between treatments (e.g., 2%) are unlikely to translate into meaningful differences in clinical decision-making and are therefore appropriate for defining equivalence