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This process can lead to the formation of new chemical entities, potentially altering the drug's safety profile and reducing its therapeutic effects

Thiazide & Thiazide-like Diuretics Site: Distal Convoluted Tubule (DCT) Thiazides: Hydrochlorothiazide Chlorothiazide Thiazide-like: Chlorthalidone Indapamide Metolazone Uses: Hypertension, mild edema, nephrogenic diabetes insipidus 5

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Methods In this multicenter randomized placebo-controlled phase 3 trial, patients with glycosylated hemoglobin (HbA1c) levels 7.0% to 10.5% ( n =283) previously used DAPA 10 mg plus MET (1,000 mg) were randomly assigned to the evogliptin 5 mg once daily or placebo group (1:1)