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[3] Sublingual and nasal preparations are available but are not routinely recommended within UK clinical guidance and may not be licensed as medicines

A series of photos showed his skin dramatically darkening with time Despite its growing popularity online, Melanotan-II is not approved for medical use

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The core trials are SURMOUNT (tirzepatide for weight management, The New England Journal of Medicine , 2022) and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)