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DSIP appears to help break this cycle through multiple mechanisms

However, melanoma of the lip, although rare, can sometimes look similar to a melanotic macule in its early stages, which is why dermatologists recommend that any new pigmented lesion on the lip, or any existing one that changes in size, color, or shape, should be evaluated to rule out a more serious diagnosis

For instance, it has been shown that psychological stress leads to HPA-dependent monocyte-mediated exacerbation of gut inflammation (246, 247), and can alter the composition of the microbiota (248), a phenomenon possibly due to the presence of neurotransmitter receptors on bacteria (245)

Arch Dermatol