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sFRPs have a Netrin-related motif in the C-terminal region, WIF has a WIF domain in the C-terminal region, and both bind to Wnt proteins, thereby inhibiting Wnt signalling

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Food and Drug Administration has specifically cited unassessed immunogenicity as a concern for this class

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Inspect the solution through the pen windowit should be clear, colourless, and free from particles

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Phase 3 ACHIEVE trial completed March 2026

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