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Critical role of FOXO3a in carcinogenesis

Upon tissue injury, locally released SDF-1 forms a chemotactic gradient that binds to CXCR4 expressed on the MSC surface, initiating intracellular signaling that guides MSC migration to the injury site (Xiao et al., 2016)

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For gastrointestinal applications, oral administration is also studied, with the same dose range delivered in capsule form