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A landmark 2025 study published in PNAS highlighted that both Long COVID and ME/CFS are fundamentally driven by elevated oxidative stress and mitochondrial damage in immune cells

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It was found a significant decrease in lymphohistiocytic infiltration in the gastric mucosa, restoration of the structure of the pancreas, and increased focal proliferation of the glandular epithelium which were considered as the signs of morphological restoration of the epithelium and reduction of the signs of its dysplasia