Candidacy in the post is not only about lab values: previous weight loss attempts, lifestyle readiness, and medication history are weighed alongside BMI and comorbidity status
In particular, the differences between FoB and MZB in recirculation properties 49 , the exposure to oxygen levels, and in degree of activation upon stimulation 48 , have raised interest in their metabolic dependencies
Two forms of human COMT have been identified, a cytoplasmic soluble form (SCOMT) and a membranebound form (MBCOMT) located in the cytosolic side of the rough endoplasmic reticulum The SCOMT is predominantly expressed in the human liver, intestine and kidney (Taskinen et al., 2003), whereas the membranebound form is more highly expressed in all regions of the human central nervous system (Tunbridge et al., 2006)
Results will vary from patient to patient, of course, but an annual weight loss of 15% has been shown to be a common outcome when using these drugs properly