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108 It is now understood that in addition to neuropathy of the enteric nervous system, the pathogenesis also involves a loss of interstitial cells of Cajal, enteric glial cell dysfunction, oxidative stress and inflammation
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For instance, a double-blind 12-month study showed administration of biotin (100 mg three times daily) reduced disability progression among individuals with progressive multiple sclerosis (64)
They have a lower risk of causing low blood sugar (hypoglycemia) compared to the older oral diabetes meds, such as sulfonylureas (tolbutamide, glypizide and glimepiride) or meglitinides (Prandin, Starlit and Glufast)
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