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Usually children and young adults Typical manifestation: pink papule on face or extremities Architecture Symmetric (often wedge shaped) Sharp peripheral borders Variation in size and shape of densely cellular nests Pagetoid melanocytes may be present focally Large spindle and epithelioid cells with abundant pink cytoplasm Evidence of maturation Rare dermal mitoses are acceptable, if present in the superficial or midportion of the lesion Secondary epidermal or stromal changes Dull pink globules (Kamino bodies) present in many but not all cases Vascular ectasia and edema Patchy lymphocytic aggregates Epidermal hyperplasia may be prominent Sclerosing variants of Spitz's nevus exist
Supporters point to a sharp increase in nitrous oxide-related criminal cases in San Diego County and testimony from local officials who described the gas as a growing public health problem
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