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2.4 Analytical and Statistical Methods 2.4.1 Trial 1 (Lisinopril/Warfarin) Sample Size Calculations Assuming the ratio between AUC values was 1.00, and the within-subject standard deviation (SD) of log(AUC 0inf ) was 0.36, then 46 subjects completing the study would yield a power of at least 80% to conclude no effect of coadministration of oral semaglutide for all three endpoints

Figure 1: Biochemical pathway of SAG and GSH

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